Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 493
interventional 439
Observational 50
Registry 4

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 175
Drug|placebo 85
Device 73
Other 45
Drug|Other 9
Procedure 8
Device|Procedure 7
Dietary Supplement|placebo 6
Biological 4
Device|Other 4
Biological|placebo 3
Device|Drug 3
Diagnostic Test 2
Dietary Supplement 2
Dietary Supplement|Other 2
Other|Procedure 2
Behavioral 1
Behavioral|Drug|Procedure 1
Biological|Drug 1
Biological|Drug|Other 1
Device|Dietary Supplement|Other 1
Diagnostic Test|Drug 1
Dietary Supplement|Drug|Other 1
Dietary Supplement|Drug|placebo 1
Drug|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 212
NA 61
Korea, Republic of 21
Austria 15
Japan 15
China 12
France 9
Singapore 9
Canada 7
Israel 7
United Kingdom 7
Mexico 6
Brazil 5
Spain 5
Italy 4
Finland 3
Taiwan 3
Argentina 2
Australia 2
Chile 2
Denmark 2
Egypt 2
France|Spain 2
Germany 2
India 2
Thailand 2
Australia|Belgium|France|Germany|Italy|Russian Federation|Spain|United Kingdom 1
Australia|Canada 1
Austria|Germany|Hungary 1
Cambodia 1
China|Singapore 1
Croatia 1
Czechia|France|Italy|Poland|Russian Federation|Spain|Turkey 1
Estonia|Germany|Italy|Portugal|Slovakia|Spain 1
France|United Kingdom 1
Greece 1
Japan|Korea, Republic of 1
Netherlands 1
Norway 1
Sweden 1
Switzerland 1
Tunisia 1
Turkey 1
United States|Australia 1
United States|Canada 1
United States|Spain|United Kingdom 1

Sites per Study

Site_count Study_Count
1 315
2 25
3 23
4 6
5 12
6 6
7 2
8 2
9 4
10 3
11 5
12 3
13 3
14 2
15 1
16 2
17 1
19 1
20 1
22 2
23 2
26 1
27 3
28 2
31 1
34 1
35 1
40 1
41 1
45 2
60 2
62 1
63 1
81 1

Phase

Phase Study_Count
N/A 158
Phase 2 92
Phase 3 79
Phase 4 66
Phase 1 15
Phase 2/Phase 3 13
Phase 1/Phase 2 12
Early Phase 1 4

Number of Arms

Number_of_Arms Count_of_Studies
1 64
2 238
3 69
4 34
5 2
6 3
8 2
NA 27

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 7.00 2.000 5.0 27.0000 9.0000 23.0000 18.0000 5.00000
1st Qu. 16.75 25.000 22.0 60.0000 72.0000 101.0000 184.2500 30.00000
Median 30.00 50.000 30.0 80.5000 150.0000 200.0000 329.5000 50.00000
Mean 29.75 234.707 34.8 107.8333 163.8202 208.4615 395.7432 67.69231
3rd Qu. 43.00 92.000 40.0 123.0000 206.0000 317.0000 597.0000 73.00000
Max. 52.00 25875.000 77.0 327.0000 765.0000 480.0000 1936.0000 334.00000

Trial Group Type

group_type Group_Count
Experimental 460
Active Comparator 239
Placebo Comparator 178
NA 27
Other 25
No Intervention 13
Sham Comparator 12

Intervention Model

intervention_model Study_Count
Parallel Assignment 312
Single Group Assignment 81
Crossover Assignment 38
NA 6
Factorial Assignment 2

Primary Purpose

primary_purpose Study_Count
Treatment 365
NA 20
Basic Science 15
Supportive Care 13
Other 9
Diagnostic 8
Prevention 5
Device Feasibility 2
Screening 2

Observational Studies

Studies by Country

Country Study_Count
United States 19
Canada 4
Singapore 4
Germany 3
NA 3
Taiwan 3
Austria 2
China 2
France 2
Korea, Republic of 2
Croatia 1
Israel 1
Norway 1
Portugal 1
Russian Federation 1
United States|France|Germany|Spain|United Kingdom 1

Sites per Study

Site_count Study_Count
1 42
2 2
5 1
6 2
8 1
10 1
17 1

Enrollment Metrics

Measure Observational
Min 1.00
1st Qu 40.00
Median 90.00
Mean 243.62
3rd Qu 238.50
Max 4000.00

Observation Model

observational_model Study_Count
Cohort 15
Case-Only 13
Case-Control 11
Case Control 7
NA 2
Ecologic or Community 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 33
Cross-Sectional 12
Retrospective 4
NA 1

Registries

Studies by Country

Country Study_Count
China 3
United Kingdom 1

Sites per Study

Site_count Study_Count
1 3
2 1

Enrollment Metrics

Measure Registries
Min 35.00
1st Qu 233.75
Median 400.00
Mean 367.50
3rd Qu 533.75
Max 635.00

Registry Model

observational_model Study_Count
Case-Control 2
Case Control 1
Cohort 1

Time Perspective

time_perspective Study_Count
Prospective 4

Follow-up

target_duration Study_Count
1 Day 2
1 Month 1
8 Weeks 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04454983 Lipiflow vs iLux Patient Acceptance and Comfort Study https://ClinicalTrials.gov/show/NCT04454983 Completed Epstein, Arthur B., OD, FAAO 2020-02-29
NCT04457999 Clinical Outcome of Lipiflow Treatment Prior to Cataract Surgery in Dry Eye Patients https://ClinicalTrials.gov/show/NCT04457999 Recruiting Samsung Medical Center 2020-07-02
NCT04457648 Manuka Honey Eye Drops VS Conventional Treatment of Meibomian Gland Dysfunction Related Dry Eye Disease https://ClinicalTrials.gov/show/NCT04457648 Completed Chinese University of Hong Kong 2020-06-01
NCT04393441 Efficacy and Safety of a New Artificial Tear Formulation Compared With Systane Ultra Multidose in Participants With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04393441 Recruiting Allergan 2020-11-27
NCT03937882 Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3 https://ClinicalTrials.gov/show/NCT03937882 Recruiting ReGenTree, LLC 2020-08-31
NCT03396913 Effectiveness of Intense Pulsed Light for Improving Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03396913 Completed Lumenis Ltd. 2019-08-15
NCT03368404 A Study to Evaluate the Performance and Safety of CBL-102 Versus Vismed® Multi Eye Drops in the Management of Dry Eye https://ClinicalTrials.gov/show/NCT03368404 Active, not recruiting Laboratoire Chauvin 2020-03-31
NCT03520348 Safety and Tolerability of the Ophthalmic Gel PRO-167 Versus Corneregel® on Healthy Subjects. https://ClinicalTrials.gov/show/NCT03520348 Completed Laboratorios Sophia S.A de C.V. 2018-05-22
NCT03821415 Effects of RP101 in Post-menopausal Women With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03821415 Completed Redwood Pharma AB 2019-11-18
NCT03334539 A Study to Assess Efficacy of HL036 in Subjects With Dry Eyes https://ClinicalTrials.gov/show/NCT03334539 Completed HanAll BioPharma Co., Ltd. 2018-05-31
NCT03333057 Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03333057 Completed Novaliq GmbH 2018-05-18
NCT03332342 Closed Eye Neutrophils in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03332342 Completed University of Alabama at Birmingham 2018-12-12
NCT03319420 Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren’s Syndrome https://ClinicalTrials.gov/show/NCT03319420 Recruiting Ocuwize LTD 2020-09-30
NCT03318874 Optimization of the Treatment of Dry Eye Disease Caused by Meibomian Gland Dysfunction https://ClinicalTrials.gov/show/NCT03318874 Active, not recruiting Oslo University Hospital 2020-04-15
NCT03302273 Corneal Epithelial Stem Cells and Dry Eye Disease https://ClinicalTrials.gov/show/NCT03302273 Enrolling by invitation Panhandle Eye Group, LLP 2021-02-01
NCT03292809 CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03292809 Completed Novaliq GmbH 2018-05-22
NCT03287635 Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03287635 Recruiting Toyos Clinic 2020-05-31
NCT03265652 IPL and MGX Versus MGX Alone in the Treatment of Dry Eye Disease Secondary to MGD https://ClinicalTrials.gov/show/NCT03265652 Completed Lumenis Ltd. 2019-04-18
NCT03265327 Effect of an Oral Supplement Containing Omega-3 and Omega-6 on Dry Eye Symptoms https://ClinicalTrials.gov/show/NCT03265327 Completed Nature’s Way Canada 2018-06-27
NCT03228784 The Effect of Ablation Depth on Dry Eye After LASIK Treatment of Myopia https://ClinicalTrials.gov/show/NCT03228784 Completed Minia University 2014-05-01
NCT03226444 Lacripepâ„¢ in Subjects With Dry Eye Associated With Primary Sjögren’s Syndrome https://ClinicalTrials.gov/show/NCT03226444 Completed TearSolutions, Inc. 2019-12-27
NCT03216096 Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03216096 Completed Santen Pharmaceutical Co., Ltd. 2018-02-01
NCT03211351 Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03211351 Completed Huaxia Eye Hospital Group 2017-12-01
NCT03208673 Optive Brand For Day And Night Dry Eye Management https://ClinicalTrials.gov/show/NCT03208673 Completed Allergan 2017-09-06
NCT03204903 Laser Acupuncture for Dry Eye https://ClinicalTrials.gov/show/NCT03204903 Recruiting Chang Gung Memorial Hospital 2019-07-31
NCT03194698 Efficacy of IPL Treatment of Dry Eye and Ocular Rosacea https://ClinicalTrials.gov/show/NCT03194698 Completed Mayo Clinic 2018-12-06
NCT03183089 Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT03183089 Completed The Mentholatum Company 2016-01-04
NCT03162783 A Randomized, Double Masked, Clinical Study of Subjects With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03162783 Completed Aldeyra Therapeutics, Inc. 2017-07-06
NCT03161080 Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03161080 Completed Medical University of Vienna 2017-05-12
NCT03141931 The Effects of Dietary Supplementation With Omega-3 Fatty Acids on Symptoms of Dry Eye https://ClinicalTrials.gov/show/NCT03141931 Completed The University of New South Wales 2018-10-19
NCT03116776 Walnut Shell Glasses Moxibustion for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03116776 Recruiting Guang’anmen Hospital of China Academy of Chinese Medical Sciences 2018-07-30
NCT03108664 HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03108664 Completed Sylentis, S.A. 2018-10-16
NCT03097614 Dry Eye Symptom Relief Assessment With Use of TrueTear in a Controlled Adverse Environment https://ClinicalTrials.gov/show/NCT03097614 Completed Oculeve, Inc. 2017-06-26
NCT03088605 Safety and Efficacy of TOP1630 for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03088605 Completed Topivert Pharma Ltd 2017-06-15
NCT03085290 Allogeneic Versus Autologous Serum Eye Drops https://ClinicalTrials.gov/show/NCT03085290 Completed Sanquin Research & Blood Bank Divisions 2018-10-08
NCT03074344 Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT03074344 Completed Azienda Ospedaliera Universitaria Policlinico “G. Martino” 2016-07-31
NCT03066219 Safety and Efficacy of BRM421 for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03066219 Completed BRIM Biotechnology Inc. 2017-05-20
NCT03052140 Lamelleye vs Comparator for the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT03052140 Completed Glasgow Caledonian University 2017-08-09
NCT03019627 An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT03019627 Completed Dompé Farmaceutici S.p.A 2017-08-31
NCT03012698 Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT03012698 Completed Epitech Mag Ltd. 2019-06-17
NCT02980913 Difference in the Frequency of Use of Lachrymal Substitutes in Patients With Moderate to Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02980913 Completed Medical University of Vienna 2016-05-17
NCT02980224 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02980224 Completed OmegaD LLC 2017-02-28
NCT02975102 A Study to Evaluate the Performance and Safety of CBL-101 Versus Vismed® Multi Eye Drops in the Management of Dry Eye https://ClinicalTrials.gov/show/NCT02975102 Completed Laboratoire Chauvin 2019-09-17
NCT02974907 Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2 https://ClinicalTrials.gov/show/NCT02974907 Completed ReGenTree, LLC 2017-09-30
NCT02951910 A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT02951910 Completed Semmelweis University 2016-08-31
NCT02917512 Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02917512 Completed Huons Co., Ltd. 2016-12-31
NCT02910713 Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation https://ClinicalTrials.gov/show/NCT02910713 Completed Allergan 2016-10-31
NCT02908282 Topical Omega-3 Fatty Acids (REMOGEN® OMEGA) in the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT02908282 Completed TRB Chemedica AG 2018-07-31
NCT02871440 A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye https://ClinicalTrials.gov/show/NCT02871440 Completed The University of New South Wales 2017-09-18
NCT02848222 Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers https://ClinicalTrials.gov/show/NCT02848222 Completed University of Alabama at Birmingham 2017-12-31
NCT02845674 An Open-Label Extension of a Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca https://ClinicalTrials.gov/show/NCT02845674 Completed Sun Pharma Global FZE 2017-08-15
NCT02819284 Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02819284 Completed Kala Pharmaceuticals, Inc. 2017-09-30
NCT02813265 Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02813265 Completed Kala Pharmaceuticals, Inc. 2017-10-31
NCT02802150 The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02802150 Completed Chonbuk National University Hospital 2015-07-31
NCT02798289 Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator https://ClinicalTrials.gov/show/NCT02798289 Completed Oculeve, Inc. 2016-08-31
NCT02776670 Clinical Outcomes Following Treatment With SYSTANE® BALANCE https://ClinicalTrials.gov/show/NCT02776670 Completed Alcon Research 2017-11-22
NCT02764814 In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye https://ClinicalTrials.gov/show/NCT02764814 Completed Tissue Tech Inc. 2016-09-30
NCT02752763 Comparison of Autologous Serum Versus Preservative Free Artificial Tear https://ClinicalTrials.gov/show/NCT02752763 Completed NiÄŸde State Hospital 2016-03-31
NCT02701764 Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis? https://ClinicalTrials.gov/show/NCT02701764 Completed University of Miami 2018-12-01
NCT02688556 Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca https://ClinicalTrials.gov/show/NCT02688556 Completed Sun Pharma Global FZE 2016-11-30
NCT02683382 Effects of a Moisturizing Product on Dry Eye and Skin https://ClinicalTrials.gov/show/NCT02683382 Completed Aromtech Ltd. 2016-06-30
NCT02680158 A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02680158 Completed Oculeve, Inc. 2016-03-31
NCT02665234 A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02665234 Completed Mimetogen Pharmaceuticals USA, Inc. 2017-02-28
NCT02634853 A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT02634853 Completed Mimetogen Pharmaceuticals USA, Inc. 2017-02-28
NCT02621593 Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD https://ClinicalTrials.gov/show/NCT02621593 Completed Lumenis Ltd. 2017-01-31
NCT02617667 CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED) https://ClinicalTrials.gov/show/NCT02617667 Completed Novaliq GmbH 2016-07-31
NCT02608489 Clinical Effects and Safety of 3% Diquafosol After Cataract Surgery https://ClinicalTrials.gov/show/NCT02608489 Completed Soonchunhyang University Hospital 2015-01-31
NCT02597803 Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-1 https://ClinicalTrials.gov/show/NCT02597803 Completed ReGenTree, LLC 2016-06-30
NCT02585648 Added Benefits of Lachrymal Substitute Gel During the Night in Patients With Moderate to Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02585648 Completed Medical University of Vienna 2016-05-31
NCT02585453 Influence of Lachrymal Substitute Gels on Tear Film Thickness in Patients With Moderate to Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02585453 Completed Medical University of Vienna 2015-09-30
NCT03404115 A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03404115 Completed Aldeyra Therapeutics, Inc. 2018-07-11
NCT02553772 A Safety and Efficacy Study of a New Eye Drop Formulation in Patients With Dry Eye Disease. https://ClinicalTrials.gov/show/NCT02553772 Completed Allergan 2016-09-09
NCT02526290 Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator https://ClinicalTrials.gov/show/NCT02526290 Completed Oculeve, Inc. 2016-04-30
NCT02510235 Tolerability, Safety and Efficacy of Lubricin Eye Drops vs Sodium Hyaluronate Eye Drops in Subjects With Mod. Dry Eye https://ClinicalTrials.gov/show/NCT02510235 Completed Dompé Farmaceutici S.p.A 2015-05-31
NCT02507934 Tolerability, Safety and Efficacy of Lubricin (150 µg/ml) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops in Patients With Moderate Dry Eye (DE) https://ClinicalTrials.gov/show/NCT02507934 Completed Dompé Farmaceutici S.p.A 2015-08-31
NCT02503189 A Phase III Study of KCT-0809 in Dry Eye Patients With Sjögren’s Syndrome https://ClinicalTrials.gov/show/NCT02503189 Completed Kissei Pharmaceutical Co., Ltd. 2017-01-31
NCT02503163 A Long-term Study of KCT-0809 in Dry Eye Patients With Sjögren’s Syndrome https://ClinicalTrials.gov/show/NCT02503163 Completed Kissei Pharmaceutical Co., Ltd. 2017-10-19
NCT02470429 Evaluation of Clinical Outcomes After the Use of SYSTANE® HYDRATION https://ClinicalTrials.gov/show/NCT02470429 Completed Alcon Research 2016-05-26
NCT02468700 OTX-14-006: A Phase 2 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT02468700 Completed Ocular Therapeutix, Inc. 2015-08-31
NCT02455050 A Study to Compare a New Eye Drop Formulation With Systane® Gel Drops and Genteal® Lubricant Gel Drops for Moderate to Severe Dry Eye Relief https://ClinicalTrials.gov/show/NCT02455050 Completed Allergan 2015-08-31
NCT02446015 Clinical Evaluation Following Use of SYSTANE® ULTRA in the Management of Dry Eye https://ClinicalTrials.gov/show/NCT02446015 Completed Alcon Research 2016-06-21
NCT02435914 Safety, Efficacy, Tolerability and Pharmacokinetics of AGN-223575 Ophthalmic Suspension in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02435914 Completed Allergan 2016-01-31
NCT02420834 Dry Eye Treatment With Artificial Tears https://ClinicalTrials.gov/show/NCT02420834 Completed Aston University 2019-01-31
NCT02420730 Safety, Tolerability and Systemic Pharmacokinetics of AGN-232411 in Healthy Participants and Participants With Dry Eye https://ClinicalTrials.gov/show/NCT02420730 Completed Allergan 2016-03-31
NCT02417116 Tear Osmolarity Clinical Utility in Dry Eye Disease https://ClinicalTrials.gov/show/NCT02417116 Completed Aston University 2019-01-31
NCT02403219 Paralysis of the Orbicularis Muscle of the Eye in the Treatment for Dry Eye https://ClinicalTrials.gov/show/NCT02403219 Completed Instituto de Oftalmología Fundación Conde de Valenciana 2014-02-28
NCT02385292 Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation https://ClinicalTrials.gov/show/NCT02385292 Completed Oculeve, Inc. 2016-03-31
NCT02380248 Clinical Evaluation of Systane® Gel Drops in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT02380248 Completed Alcon Research 2016-06-01
NCT02369861 Study of ST266 Eye Drops in Treating Dry Eye https://ClinicalTrials.gov/show/NCT02369861 Completed Noveome Biotherapeutics, formerly Stemnion 2015-10-31
NCT02365519 LME636 in the Relief of Persistent Ocular Discomfort in Subjects With Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT02365519 Completed Alcon Research 2015-10-16
NCT02326090 Phase 2 Study With Cis-UCA Ophthalmic Solutions in Subjects With Dry Eye https://ClinicalTrials.gov/show/NCT02326090 Completed Herantis Pharma Plc. 2015-04-30
NCT02313454 Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT02313454 Completed Allergan 2015-04-08
NCT02284516 A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3) https://ClinicalTrials.gov/show/NCT02284516 Completed Shire 2015-10-05
NCT02280473 A Safety and Efficacy Study of Refresh Optive® Gel Drops in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02280473 Completed Allergan 2015-03-16
NCT02260960 The Influence of PRN Dry Eye Omega-3 Nutritional Regimen on Tear Osmolarity In Cases Of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02260960 Completed Physician Recommended Nutriceuticals 2015-03-31
NCT02254265 Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Sicca https://ClinicalTrials.gov/show/NCT02254265 Completed Sun Pharma Global FZE 2015-05-31
NCT02242032 Study of the Safety and Tolerability of P 321 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02242032 Completed Parion Sciences 2015-03-31
NCT02235259 Efficacy and Safety of XG-104 for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT02235259 Completed Xigen SA 2015-02-28
NCT02229955 Study of Tisporin Eye Drops Group and Restasis Eye Drops Group After Treatment, Each Treatment Group Comparisons for Evaluation of Efficacy and Safety in Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT02229955 Completed Hanlim Pharm. Co., Ltd. 2014-04-30
NCT02219204 Randomised Research Comparing Acupuncture, Herbal Treatment and Artificial Tear Eye Drops in Dry Eye https://ClinicalTrials.gov/show/NCT02219204 Completed Singapore National Eye Centre 2015-12-31
NCT02210793 Dry Eye Evaluation After Transepithelial PRK https://ClinicalTrials.gov/show/NCT02210793 Completed AL-Nour Eye Hospital 2013-03-31
NCT02205840 A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye. https://ClinicalTrials.gov/show/NCT02205840 Completed Seikagaku Corporation 2014-11-30
NCT02188160 Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02188160 Completed Kala Pharmaceuticals, Inc. 2015-01-31
NCT02147509 Evaluation of Therapeutic Effect of Bandage Contact Lenses ( BCL) on Dry Eye Caused by Sjogren’s Syndrome https://ClinicalTrials.gov/show/NCT02147509 Completed Wenzhou Medical University 2014-04-30
NCT02139033 A Phase 4 Study Investigating the Efficacy of Retaineâ„¢ in Managing Signs and Symptoms Associated With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02139033 Completed Ocusoft, Inc. 2014-05-31
NCT02128763 Dry Eye Assessment and Management Study https://ClinicalTrials.gov/show/NCT02128763 Completed University of Pennsylvania 2017-09-05
NCT02121301 A Clinical Study to Assess the Safety and Efficacy of an Ophthalmic Solution (SkQ1) in the Treatment of Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02121301 Completed Mitotech, SA 2014-05-31
NCT02120079 The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED https://ClinicalTrials.gov/show/NCT02120079 Completed Tufts Medical Center 2017-04-30
NCT02117687 A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye https://ClinicalTrials.gov/show/NCT02117687 Completed Allergan 2015-01-27
NCT02116244 Civamide Nasal Solution for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT02116244 Completed Winston Laboratories 2015-09-30
NCT02102464 Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers https://ClinicalTrials.gov/show/NCT02102464 Completed TearScience, Inc. 2015-08-31
NCT02101281 Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT02101281 Completed Dompé Farmaceutici S.p.A 2015-01-31
NCT02092207 Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02092207 Completed Yungjin Pharm. Co., Ltd. 2014-06-30
NCT02078661 Safety and Efficacy of PG101 for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02078661 Completed Rhodes Pharmaceuticals, L.P. 2014-01-31
NCT01311609 A Multi-Site Post Marketing Surveillance Study for Systane in Indian Patients https://ClinicalTrials.gov/show/NCT01311609 Completed Alcon Research 2011-07-31
NCT01294956 A Clinical Evaluation of an Investigational Lubricant Eye Gel (FID 115958D) https://ClinicalTrials.gov/show/NCT01294956 Completed Alcon Research 2011-04-30
NCT01294384 Safety and Efficacy Study of New Eye Drop Formulations With Refresh Tears® in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01294384 Completed Allergan 2012-09-25
NCT01278784 Local Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers https://ClinicalTrials.gov/show/NCT01278784 Completed Medical University of Vienna 2011-06-30
NCT01276223 Evaluation of Anti-Inflammatory Treatment in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01276223 Completed Alcon Research 2012-01-31
NCT02023268 Efficacy and Safety of T2762 and Vismed® in Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02023268 Completed Laboratoires Thea 2014-12-31
NCT02051023 Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca) https://ClinicalTrials.gov/show/NCT02051023 Completed Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA 2014-12-31
NCT02040623 Safety and Efficacy Study of R932348 Ophthalmic Solution in Chronic Ocular Graft Versus Host Disease Patients(DROPS-2) https://ClinicalTrials.gov/show/NCT02040623 Completed Rigel Pharmaceuticals 2016-07-31
NCT02028754 A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms https://ClinicalTrials.gov/show/NCT02028754 Completed Allergan 2013-05-31
NCT03785340 Study of Brimonidine Tartrate Nanoemulsion Eye Drop Solution in the Treatment of Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03785340 Completed Ocugen 2019-02-28
NCT02014922 A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN) https://ClinicalTrials.gov/show/NCT02014922 Completed University of Waterloo 2014-11-30
NCT02004067 Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02004067 Completed Federal University of São Paulo 2016-08-31
NCT01998802 Phase 3 Study of EBI-005 in Dry Eye Disease https://ClinicalTrials.gov/show/NCT01998802 Completed Eleven Biotherapeutics 2015-03-31
NCT01991132 Validating the Diagnostic Accuracy of Mediview 2.0 Software as an Image Analysis Tool of Meibomian Glands https://ClinicalTrials.gov/show/NCT01991132 Completed Singapore National Eye Centre 2014-12-31
NCT01967147 Clinical Outcomes Following Treatment With Systane® Balance in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT01967147 Completed Alcon Research 2015-01-31
NCT01960010 A Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT01960010 Completed Mimetogen Pharmaceuticals USA, Inc. 2014-08-31
NCT01959854 Efficacy of Topical 0.2% Xanthan Gum in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01959854 Completed SIFI SpA 2014-10-31
NCT01933178 Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis https://ClinicalTrials.gov/show/NCT01933178 Completed Singapore National Eye Centre 2014-02-28
NCT01918410 Effect of Contact Lens With Alginic Acid in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01918410 Completed Singapore National Eye Centre 2014-12-31
NCT01900249 To Assess the Safety and Efficacy of R932348 Ophthalmic Solutions in Patients With Keratoconjunctivitis Sicca https://ClinicalTrials.gov/show/NCT01900249 Completed Rigel Pharmaceuticals 2014-07-31
NCT01880463 Dry Eye Disease in the Vitamin D and Omega-3 Trial (VITAL) https://ClinicalTrials.gov/show/NCT01880463 Active, not recruiting Brigham and Women’s Hospital 2020-12-31
NCT01864330 Influence of Lachrymal Substitutes on Tear Film Thickness in Patients With Moderate Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01864330 Completed Medical University of Vienna 2013-08-31
NCT01863368 Clinical Evaluation of Systane® ULTRA Compared to OPTIVE® in Ocular Surface Staining https://ClinicalTrials.gov/show/NCT01863368 Completed Alcon Research 2014-06-30
NCT01850979 Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops https://ClinicalTrials.gov/show/NCT01850979 Completed University of Sao Paulo General Hospital 2011-11-30
NCT01843894 A Phase 1/2, RU-101 Ophthalmic Solution in Patients With Severe Dry Eye https://ClinicalTrials.gov/show/NCT01843894 Completed R-Tech Ueno, Ltd. 2014-07-31
NCT01833117 Efficacy and Safety Study of FID 119515A https://ClinicalTrials.gov/show/NCT01833117 Completed Alcon Research 2013-06-30
NCT01817582 Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease) https://ClinicalTrials.gov/show/NCT01817582 Completed Bausch & Lomb Incorporated 2014-01-10
NCT01804361 Efficacy and Safety Study of Haporine-S for Treatment of Moderate to Severe Dry Eye Syndromes https://ClinicalTrials.gov/show/NCT01804361 Completed DH Bio Co., Ltd. 2014-02-28
NCT01797822 Effects of Dry Eye Treatments on the Ocular Surface https://ClinicalTrials.gov/show/NCT01797822 Completed Baylor College of Medicine 2015-12-31
NCT01776658 Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain https://ClinicalTrials.gov/show/NCT01776658 Completed Sylentis, S.A. 2015-04-30
NCT01775540 Systane Ultra Versus Maxidex Versus Saline https://ClinicalTrials.gov/show/NCT01775540 Completed Icahn School of Medicine at Mount Sinai 2012-10-31
NCT01768312 Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group https://ClinicalTrials.gov/show/NCT01768312 Completed Hanlim Pharm. Co., Ltd. 2013-07-31
NCT01753752 Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation https://ClinicalTrials.gov/show/NCT01753752 Completed Medical University of Vienna 2013-03-31
NCT01753687 Correlation of Different Signs for Assessment of Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01753687 Completed Medical University of Vienna 2013-07-31
NCT01748578 Phase 1 Study for Safety and Tolerability of EBI-005 Topically Administered to Eyes of Healthy Adult Subjects https://ClinicalTrials.gov/show/NCT01748578 Completed Eleven Biotherapeutics 2012-11-30
NCT01745887 A Multi-Center Study Subjects With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01745887 Completed Eleven Biotherapeutics 2012-11-30
NCT01744457 Reproducibility of Tearfilm Osmolarity Measurements Using TearLab® in Patients With Dry Eye Syndrome and Healthy Subjects https://ClinicalTrials.gov/show/NCT01744457 Completed Medical University of Vienna 2012-02-29
NCT01743729 A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye https://ClinicalTrials.gov/show/NCT01743729 Completed Shire 2013-10-01
NCT01742884 Efficacy and Safety of a Treatment for Dry Eye Syndrome: Thealoz https://ClinicalTrials.gov/show/NCT01742884 Completed Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA 2014-06-30
NCT01733992 A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01733992 Completed Rigel Pharmaceuticals 2013-02-28
NCT01733745 SYSTANE® Family - Meibomian Deficiency https://ClinicalTrials.gov/show/NCT01733745 Completed Alcon Research 2013-06-30
NCT01733732 SYSTANE® BALANCE Symptoms (OSDI) & Inflammatory Biomarkers https://ClinicalTrials.gov/show/NCT01733732 Completed Alcon Research 2013-10-31
NCT01692145 A Parallel Group Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes https://ClinicalTrials.gov/show/NCT01692145 Completed Kissei Pharmaceutical Co., Ltd. NA
NCT01688726 Evaluation of SYSTANE® BALANCE in Dry Eye Subjects With Lipid Deficiency https://ClinicalTrials.gov/show/NCT01688726 Completed Alcon Research 2013-11-30
NCT01684436 Safety and Efficacy of Punctal Plug Insertion in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01684436 Completed Allergan 2013-07-31
NCT01682460 Pilot Study on the Use of Artificial Tears to Treat Dry Eye in Glaucoma Patients https://ClinicalTrials.gov/show/NCT01682460 Completed University of Waterloo 2013-04-30
NCT01675570 A Study of RX-10045 in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT01675570 Completed C.T. Development America, Inc. 2012-11-30
NCT01670357 Phase II Study of DA-6034 Eye Drops in Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01670357 Completed Dong-A ST Co., Ltd. 2013-03-31
NCT01664949 A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVEâ„¢ in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01664949 Completed Allergan 2014-05-31
NCT01660256 Confirmatory Study of OPC-12759 Ophthalmic Solution https://ClinicalTrials.gov/show/NCT01660256 Completed Otsuka Pharmaceutical Co., Ltd. 2013-03-31
NCT01657253 Efficacy and Safety of PRO-148 Versus Systane®, in Patients With Mild to Moderate Dry Eye https://ClinicalTrials.gov/show/NCT01657253 Completed Laboratorios Sophia S.A de C.V. 2015-02-28
NCT01650584 Evaluation of Ocular Comfort With ISTA Tears vs Systane https://ClinicalTrials.gov/show/NCT01650584 Completed Bausch & Lomb Incorporated 2012-12-31
NCT01636206 Safety Study of Lifitegrast to Treat Dry Eye https://ClinicalTrials.gov/show/NCT01636206 Completed Shire 2014-03-03
NCT01632137 Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01632137 Completed Kubota Vision Inc. 2013-06-30
NCT01614847 Tear Osmolarity Changes After Instilling Isotonic Hyaluronate Artificial Tears https://ClinicalTrials.gov/show/NCT01614847 Completed Northeastern State University 2012-08-31
NCT01614600 Clinical Evaluation of a Daily Disposable Contact Lens in Symptomatic Weekly/Monthly Lens Wearers https://ClinicalTrials.gov/show/NCT01614600 Completed Alcon Research 2012-09-30
NCT01601028 Hydroxychloroquine Treatment of Dry Eyes in Patients With Primary Sjögren’s Syndrome https://ClinicalTrials.gov/show/NCT01601028 Completed Seoul National University Hospital 2013-08-31
NCT01579539 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy https://ClinicalTrials.gov/show/NCT01579539 Completed Medical University of Vienna 2017-05-18
NCT01568593 Comparison of the Efficacy and Safety of T2750 and Vismed® in the Treatment of Moderate to Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01568593 Completed Laboratoires Thea 2013-03-31
NCT01562795 Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT01562795 Completed Wenzhou Medical University 2012-06-30
NCT01558999 A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01558999 Completed Seikagaku Corporation 2012-07-31
NCT01543061 Efficacy Study of a New Eyedrop on Silicone Hydrogel Contact Lens Wearers With Dry Eye Complaints https://ClinicalTrials.gov/show/NCT01543061 Completed Optometric Technology Group Ltd 2012-09-30
NCT01541891 Efficacy and Safety of PRO-148 Ophthalmic Solution Versus SYSTANE® in the Treatment of Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01541891 Completed Laboratorios Sophia S.A de C.V. 2012-03-31
NCT01521507 Randomized Controlled Trial of Long-term Treatment Effectiveness for Meibomian Gland Dysfunction (MGD) and Dry Eye https://ClinicalTrials.gov/show/NCT01521507 Completed TearScience, Inc. 2013-11-30
NCT01483989 In Vivo Measurement of Corneal Epithelial Changes in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01483989 Completed Alcon Research 2011-06-30
NCT01468168 A Study Assessing the Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01468168 Completed Santen Inc. 2012-11-30
NCT01459588 Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01459588 Completed Allergan 2012-02-15
NCT01434277 Safety Evaluation of a New Preservative in a Lubricating Eye Drop https://ClinicalTrials.gov/show/NCT01434277 Completed Johnson & Johnson Consumer and Personal Products Worldwide 2011-04-30
NCT01427816 A Phase II Study of KCT-0809 in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01427816 Completed Kissei Pharmaceutical Co., Ltd. NA
NCT01421498 Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1) https://ClinicalTrials.gov/show/NCT01421498 Completed Shire 2012-04-28
NCT01393132 Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye https://ClinicalTrials.gov/show/NCT01393132 Completed Michigan Cornea Consultants, PC 2012-12-31
NCT01388426 Moisture Chamber Glasses for Dry Eye in Asian Population https://ClinicalTrials.gov/show/NCT01388426 Completed Singapore National Eye Centre 2012-08-31
NCT01382225 Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01382225 Completed Alcon Research 2012-05-31
NCT01375582 Objective Evaluation of Ocular Surface Lubricants in Two Environments https://ClinicalTrials.gov/show/NCT01375582 Completed University of Rochester 2012-06-30
NCT01363414 Sodium Hyaluronate and Wavefront Aberrations in Dry Eyes https://ClinicalTrials.gov/show/NCT01363414 Completed Ramathibodi Hospital 2010-06-30
NCT01339936 Evaluation of the Effect of Repeated Usage on the Tear Film Characteristics of an Investigational Eye Drop in Dry Eye Sufferers https://ClinicalTrials.gov/show/NCT01339936 Completed Optometric Technology Group Ltd 2011-08-31
NCT01319773 Study of Two Formulations of Cyclosporine Ophthalmic Emulsion in Healthy Volunteers and in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01319773 Completed Allergan 2011-01-31
NCT04425551 Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction https://ClinicalTrials.gov/show/NCT04425551 Active, not recruiting Naval Hospital, Athens 2020-09-30
NCT04384991 HU007 Eye Drops in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT04384991 Completed Huons Co., Ltd. 2019-12-05
NCT04362670 Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease. https://ClinicalTrials.gov/show/NCT04362670 Active, not recruiting Ocular Therapeutix, Inc. 2020-11-30
NCT04343287 A Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of BRM421 for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT04343287 Recruiting BRIM Biotechnology Inc. 2020-04-30
NCT04342988 Effect of Cequa Treatment on Accuracy of Pre-operative Biometry & Higher Order Aberrations in Dry Eye Patients Undergoing Cataract Surgery https://ClinicalTrials.gov/show/NCT04342988 Active, not recruiting Research Insight LLC 2020-11-30
NCT04320563 Rexon-Eye in Dry Eye https://ClinicalTrials.gov/show/NCT04320563 Recruiting Singapore National Eye Centre 2021-11-30
NCT04310969 Clinical Effect of MiboFlo in Dry Eye Patients https://ClinicalTrials.gov/show/NCT04310969 Enrolling by invitation Beijing Tongren Hospital 2020-05-30
NCT04268069 Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye https://ClinicalTrials.gov/show/NCT04268069 Recruiting ORA, Inc. 2020-07-31
NCT04260893 Prospective Study To Assess The Safety And Effectiveness Of Tixel Treatment On Dry Eye Symptoms In Asian Patients https://ClinicalTrials.gov/show/NCT04260893 Recruiting Novoxel Ltd. 2021-04-30
NCT03452397 Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study) https://ClinicalTrials.gov/show/NCT03452397 Completed Oyster Point Pharma, Inc. 2018-05-16
NCT04237012 ACCURATE Study for Subjects With Dry Eyes https://ClinicalTrials.gov/show/NCT04237012 Recruiting The Eye Centers of Racine and Kenosha 2020-12-30
NCT04213248 Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD https://ClinicalTrials.gov/show/NCT04213248 Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University 2020-05-31
NCT04206020 Vehicle-Controlled Study of SkQ1 as Treatment for Dry-eye Syndrome https://ClinicalTrials.gov/show/NCT04206020 Recruiting Mitotech, SA 2020-09-15
NCT04201574 Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04201574 Recruiting Allysta Pharmaceutical 2020-08-31
NCT04184999 Effect of Intraoperative Dexamethasone on Post-op Dry Eye https://ClinicalTrials.gov/show/NCT04184999 Active, not recruiting SR Cornea Consultants 2019-12-31
NCT04181593 Phase 3 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT04181593 Recruiting OmegaD LLC 2020-07-31
NCT04172961 Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days https://ClinicalTrials.gov/show/NCT04172961 Recruiting Toyos Clinic 2020-05-01
NCT04165785 Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Dry Eye Disease https://ClinicalTrials.gov/show/NCT04165785 Completed First Affiliated Hospital of Harbin Medical University 2019-06-28
NCT04159935 Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease https://ClinicalTrials.gov/show/NCT04159935 Recruiting University of Waterloo 2020-06-30
NCT04147650 Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT04147650 Recruiting Aurinia Pharmaceuticals Inc. 2020-05-30
NCT04144413 3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin) https://ClinicalTrials.gov/show/NCT04144413 Recruiting Santen SAS 2023-05-31
NCT04143841 Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT04143841 Recruiting Epitech Mag Ltd. 2020-10-31
NCT04139122 Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04139122 Completed Senju Pharmaceutical Co., Ltd. 2020-03-03
NCT04125134 Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests https://ClinicalTrials.gov/show/NCT04125134 Recruiting Tufts Medical Center 2020-05-31
NCT04120584 Clinical Evaluation of Safety and Efficacy of Radio Frequency (Forma Eye) Treatment for Dry Eye Disease Due to Meibomian Gland Dysfunction https://ClinicalTrials.gov/show/NCT04120584 Recruiting InMode MD Ltd. 2020-10-31
NCT04115800 Liposomal Sirolimus in Dry Eye Disease https://ClinicalTrials.gov/show/NCT04115800 Recruiting Instituto de Oftalmología Fundación Conde de Valenciana 2020-05-01
NCT04105842 Refitting Daily Disposable Contact Lens Wearers With Dry Eye Disease With A Different Daily Disposable Lens Type https://ClinicalTrials.gov/show/NCT04105842 Recruiting University of Waterloo 2020-02-28
NCT04100031 Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Cataract Surgery https://ClinicalTrials.gov/show/NCT04100031 Recruiting Second Affiliated Hospital, School of Medicine, Zhejiang University 2020-06-06
NCT04096898 Senofilcon A Lenses in Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT04096898 Recruiting University of Illinois at Chicago 2020-12-31
NCT04092907 A Study Evaluating the Efficacy and Safety on Moderate to Severe Dry Eye https://ClinicalTrials.gov/show/NCT04092907 Completed Harbour BioMed (Guangzhou) Co. Ltd. 2019-07-03
NCT04091581 Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye https://ClinicalTrials.gov/show/NCT04091581 Completed University of Waterloo 2020-02-06
NCT04084483 A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT04084483 Completed Kowa Research Institute, Inc. 2020-01-03
NCT04081610 Clinical Trial to Evaluate the Safety and Tolerability of Lagricel® Ofteno Multi-dose Ophthalmic Solution https://ClinicalTrials.gov/show/NCT04081610 Recruiting Laboratorios Sophia S.A de C.V. 2019-12-20
NCT04063644 Quality of Life and Visual Acuity of Visglyc Eye Drops on Dry Eye Patients https://ClinicalTrials.gov/show/NCT04063644 Recruiting OPKO Health, Inc. 2020-05-31
NCT04036292 Clinical Trial to Evaluate the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET-2 Study) https://ClinicalTrials.gov/show/NCT04036292 Active, not recruiting Oyster Point Pharma, Inc. 2020-05-08
NCT04030962 A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04030962 Recruiting Allergan 2020-09-30
NCT04022382 A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion https://ClinicalTrials.gov/show/NCT04022382 Completed The Eye Care Institute 2019-08-26
NCT04015219 Management of Signs and Symptoms Associated With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04015219 Recruiting Tissue Tech Inc. 2020-07-01
NCT03992482 IVIG-eye Drops Treatment for Dry Eye Disease https://ClinicalTrials.gov/show/NCT03992482 Completed University of Illinois at Chicago 2019-08-02
NCT03992287 Efficacy and Safety of Hydrolysed Red Ginseng Extract on Dry Eye https://ClinicalTrials.gov/show/NCT03992287 Recruiting Chonbuk National University Hospital 2020-03-30
NCT03982368 A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye https://ClinicalTrials.gov/show/NCT03982368 Recruiting Dompé Farmaceutici S.p.A 2020-03-31
NCT03956225 Comparison Between iLux and LipiFlow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-month, Multicenter Study https://ClinicalTrials.gov/show/NCT03956225 Active, not recruiting Alcon Research 2020-10-31
NCT03925727 Tavilermide Ophthalmic Solution for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT03925727 Recruiting Mimetogen Pharmaceuticals USA, Inc. 2020-02-29
NCT03923244 Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface https://ClinicalTrials.gov/show/NCT03923244 Completed University Hospital, Clermont-Ferrand 2020-03-06
NCT03916042 A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial of Reproxalap to Assess the Safety and Efficacy in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03916042 Active, not recruiting Aldeyra Therapeutics, Inc. 2020-04-30
NCT03907865 Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation https://ClinicalTrials.gov/show/NCT03907865 Completed Medical University of Vienna 2018-11-28
NCT03889886 Study to Evaluate the Safety and Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03889886 Active, not recruiting Silk Technologies, Ltd. 2020-01-31
NCT03879863 The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03879863 Active, not recruiting Aldeyra Therapeutics, Inc. 2021-04-30
NCT03874429 Efficacy of T2259 in DED https://ClinicalTrials.gov/show/NCT03874429 Recruiting Laboratoires Thea 2020-03-01
NCT03873246 Clinical Trial to Evaluate the Chronic Efficacy of OC-01 Nasal Spray on Signs of Dry Eye Disease (The MYSTIC Study) https://ClinicalTrials.gov/show/NCT03873246 Completed Oyster Point Pharma, Inc. 2020-01-07
NCT03865888 Comparing Effect of Topical Tacrolimus 0.03% Versus Cyclosporine 0.05% in Dry Eyes of Secondary Sjogren Syndrome https://ClinicalTrials.gov/show/NCT03865888 Completed Cairo University 2019-02-01
NCT03857919 TearCare System to Treat Dry Eye Disease https://ClinicalTrials.gov/show/NCT03857919 Recruiting Sight Sciences, Inc. 2019-10-31
NCT03846453 A Study to Assess Efficacy and Safety of HL036 in Subjects With Dry Eyes https://ClinicalTrials.gov/show/NCT03846453 Recruiting HanAll BioPharma Co., Ltd. 2019-11-30
NCT03833882 Evaluation of MAF-1217 in Patients With DED https://ClinicalTrials.gov/show/NCT03833882 Completed VISUfarma SpA 2019-06-19
NCT03833388 Study of TOP1630 for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03833388 Completed Topivert Pharma Ltd 2019-05-14
NCT03830359 T2769 in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03830359 Completed Laboratoires Thea 2019-02-18
NCT03827564 Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03827564 Recruiting Allergan 2020-06-30
NCT03803748 A Non-inferiority Study of Eyestil® Plus Multidose Versus Vismed Multi® https://ClinicalTrials.gov/show/NCT03803748 Recruiting SIFI SpA 2020-06-30
NCT03803722 To Demonstrate the Non-inferiority of Eyestil Protection® Compared to Vismed® in Terms of Clinical Performance https://ClinicalTrials.gov/show/NCT03803722 Recruiting SIFI SpA 2020-06-30
NCT03788486 Efficacy and Safety of Meibomian Gland Dysfunction and Dry Eye With an LED Blue Treatment Device https://ClinicalTrials.gov/show/NCT03788486 Recruiting Toyos Clinic 2020-06-01
NCT03764735 Study of SkQ1 as Treatment for Dry-eye Syndrome https://ClinicalTrials.gov/show/NCT03764735 Completed Mitotech, SA 2019-02-09
NCT03723811 Clinical Study to Investigate the Efficacy and Safety of SJP002 Ophthalmic Solution in Patients With Dry Eye Syndrome. https://ClinicalTrials.gov/show/NCT03723811 Active, not recruiting Samjin Pharmaceutical Co., Ltd. 2018-06-25
NCT03723798 Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. https://ClinicalTrials.gov/show/NCT03723798 Active, not recruiting Samjin Pharmaceutical Co., Ltd. 2018-10-08
NCT03719885 TrueTear in Sjogren’s Disease Patients https://ClinicalTrials.gov/show/NCT03719885 Recruiting University of Pennsylvania 2019-07-25
NCT03709641 A Study to Evaluate the Safety and Effectiveness of Restylane-Defyne for Punctual Occlusion https://ClinicalTrials.gov/show/NCT03709641 Completed The Eye Care Institute 2018-11-28
NCT03706443 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops https://ClinicalTrials.gov/show/NCT03706443 Completed Ohio State University 2019-02-28
NCT03693183 Efficacy Study of Ketorolac and HPMC to Treat Dry Eye https://ClinicalTrials.gov/show/NCT03693183 Completed ORA, Inc. 2009-06-15
NCT03691636 Eyelash Prostheses Compared to 5.0% Lifitegrast BID for Dry Eye Disease. https://ClinicalTrials.gov/show/NCT03691636 Recruiting D.E.L., LLC 2019-04-02
NCT03688802 Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation (The IMPERIAL Study) https://ClinicalTrials.gov/show/NCT03688802 Completed Oyster Point Pharma, Inc. 2019-09-30
NCT03682809 Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort https://ClinicalTrials.gov/show/NCT03682809 Completed University of Alabama at Birmingham 2019-03-23
NCT03676335 Assess the Safety and Efficacy of CsA Ophthalmic Gel in Subjects With Dry Eye https://ClinicalTrials.gov/show/NCT03676335 Completed Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. 2019-06-30
NCT03666884 The Comparison of 50% AS Versus PFAT+ 0.05 % COE in Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03666884 Completed Usak State Hospital 2016-03-15
NCT03660475 Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects https://ClinicalTrials.gov/show/NCT03660475 Completed Total Eye Care, PA 2018-11-01
NCT03658811 Intense Pulse Light Treatment With Meibomian Gland Expression of the Upper Eyelids in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03658811 Completed Toyos Clinic 2018-10-30
NCT03652051 A Multicenter Study Evaluating AZR-MD-001 in Patients With Meibomian Gland Dysfunction and Evaporative Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03652051 Recruiting Azura Ophthalmics 2020-12-31
NCT03640351 Clinical Effects of Diquas-S for Patients With Dry Eye After Cataract Surgery https://ClinicalTrials.gov/show/NCT03640351 Recruiting Yonsei University 2019-08-14
NCT03636061 Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET-1 Study) https://ClinicalTrials.gov/show/NCT03636061 Completed Oyster Point Pharma, Inc. 2018-09-26
NCT03633461 Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The RAINIER Study) https://ClinicalTrials.gov/show/NCT03633461 Completed Oyster Point Pharma, Inc. 2018-09-20
NCT03617315 Crosslinked Hyaluronic Acid With Liposomes and Crocin in Dry Eye https://ClinicalTrials.gov/show/NCT03617315 Completed University of Seville 2018-02-01
NCT03616899 Safety and Efficacy of KPI-121 in Subjects With DED https://ClinicalTrials.gov/show/NCT03616899 Completed Kala Pharmaceuticals, Inc. 2020-02-05
NCT03608761 Comparison Between Rebamipide 2% Versus Autologous Serum https://ClinicalTrials.gov/show/NCT03608761 Completed Hospital Nacional Profesor Alejandro Posadas 2017-10-09
NCT03598699 A Study to Evaluate the Safety, Tolerability, Systemic Pharmacokinetics, and Pharmacodynamics of AXR-159 Ophthalmic Solution in Patients With Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03598699 Active, not recruiting AxeroVision, Inc. 2019-03-31
NCT03597139 Ocular Tolerability of Voclosporin Ophthalmic Solution Versus Restasis® in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03597139 Completed Aurinia Pharmaceuticals Inc. 2018-11-09
NCT03588624 Study of the TearCare System in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03588624 Recruiting Sight Sciences, Inc. 2018-09-30
NCT03569202 Piiloset Trehalose Emulsion Eye Drop Study in Moderate or Severe Dry Eye https://ClinicalTrials.gov/show/NCT03569202 Completed Kuopio University Hospital 2018-11-08
NCT03527212 A Study to Assess the Safety and Effectiveness of SJP-0035 for the Treatment of Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03527212 Completed Senju Pharmaceutical Co., Ltd. 2019-03-15
NCT03519815 Clinical Study to Evaluate the Efficacy of Ectoin® Containing Eye Spray for Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT03519815 Completed University of Applied Sciences and Arts Northwestern Switzerland 2018-10-30
NCT03492541 Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03492541 Completed Alcon Research 2019-04-30
NCT03467490 Self-care Management Program for Dry Eye Disease Patients Using the heiQ https://ClinicalTrials.gov/show/NCT03467490 Active, not recruiting Lawson Health Research Institute 2019-01-19
NCT03436576 Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye https://ClinicalTrials.gov/show/NCT03436576 Enrolling by invitation Pontificia Universidad Catolica de Chile 2018-10-19
NCT03418727 Dry Eye Disease Study With Brimonidine https://ClinicalTrials.gov/show/NCT03418727 Completed Ocugen 2018-03-29
NCT03418259 Intra-Nasal Mechanical Stimulation (INMEST) as a Treatment of Keratoconjunctivitis Sicca (Dry Eye Syndrome) https://ClinicalTrials.gov/show/NCT03418259 Recruiting Karolinska Institutet 2021-12-31
NCT03417505 Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye https://ClinicalTrials.gov/show/NCT03417505 Completed Tangible Science 2019-01-04
NCT03414645 Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease https://ClinicalTrials.gov/show/NCT03414645 Recruiting Cambium Medical Technologies LLC 2019-09-30
NCT01268735 The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye https://ClinicalTrials.gov/show/NCT01268735 Completed University of Zagreb 2009-09-30
NCT01257607 Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT01257607 Completed Mimetogen Pharmaceuticals USA, Inc. 2011-05-31
NCT01250171 The Effects of a Single Intravenous Administration of Secukinumab (AIN457) or Canakinumab (ACZ885) in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01250171 Completed Novartis 2011-09-30
NCT01240382 Phase III Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01240382 Completed Santen Pharmaceutical Co., Ltd. 2008-02-29
NCT01239069 Safety and Efficacy Study of DE-110 Ophthalmic Suspension for the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT01239069 Completed Santen Inc. 2011-10-31
NCT01235234 Trial of CF101 to Treat Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01235234 Completed Can-Fite BioPharma 2013-11-30
NCT01223040 An Open-Label, Single-Center Study Evaluating the Effect of Systane Balance on Video Ocular Protection Index (OPI) and Blink Patterns in Patients Diagnosed With Dry Eye https://ClinicalTrials.gov/show/NCT01223040 Completed Alcon Research 2010-09-30
NCT01212471 A Dose Ranging Study to Evaluate Safety and Efficacy of Bromfenac Ophthalmic Solution in Dry Eye Disease https://ClinicalTrials.gov/show/NCT01212471 Completed Bausch & Lomb Incorporated 2011-08-31
NCT01211951 A Study of KCT-0809 in Patients With Dry Eye Syndromes https://ClinicalTrials.gov/show/NCT01211951 Completed Kissei Pharmaceutical Co., Ltd. NA
NCT01203540 Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients https://ClinicalTrials.gov/show/NCT01203540 Completed Laboratoires Thea NA
NCT01189032 Late Phase II Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01189032 Completed Santen Pharmaceutical Co., Ltd. 2006-07-31
NCT01178242 Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome. https://ClinicalTrials.gov/show/NCT01178242 Completed Federal University of São Paulo 2010-04-30
NCT01165164 An Evaluation of the Nighttime Retention of Effect of an Investigational Lubricant Eye Drop (FID 115958D) https://ClinicalTrials.gov/show/NCT01165164 Completed Alcon Research 2010-07-31
NCT01163643 Study to Assess the Safety and Efficacy of BOL-303242-X Ophthalmic Suspension in Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01163643 Completed Bausch & Lomb Incorporated 2011-06-30
NCT01160133 To Evaluate the Physical Effects of Systane(R) Lubricant Eye Drops Compared to Refresh Tears(R) Lubricant Eye Drops https://ClinicalTrials.gov/show/NCT01160133 Completed Alcon Research 2011-06-30
NCT01139372 An Evaluation of the Daytime Use of an Investigational Lubricant Eye Drop https://ClinicalTrials.gov/show/NCT01139372 Completed Alcon Research 2010-06-30
NCT01135511 A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01135511 Completed Pfizer 2011-04-30
NCT01129856 Safety and Efficacy Study of EGP-437 (Dexamethasone Phosphate Formulated for Ocular Iontophoresis) to Treat Dry Eye https://ClinicalTrials.gov/show/NCT01129856 Completed Eyegate Pharmaceuticals, Inc. 2011-01-31
NCT01128049 Non-invasive Tear Film Dynamic Measurements in Normal, MGD and ADDE Subjects After Saline Instillation https://ClinicalTrials.gov/show/NCT01128049 Completed University of Rochester 2011-12-31
NCT01118754 Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01118754 Completed Santen Inc. 2010-12-31
NCT01107964 Oral Omega-3 Fatty Acids in the Treatment of Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT01107964 Completed Milton S. Hershey Medical Center 2014-08-31
NCT01105910 Efficacy of Systane Ultra in Post Menopausal Women With Dry Eye https://ClinicalTrials.gov/show/NCT01105910 Completed Alcon Research 2010-12-31
NCT01105624 A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Rewetting Drops in Subjects With History and Current Complaint of Contact Lens-Related Dry Eye (CLDE) https://ClinicalTrials.gov/show/NCT01105624 Completed Merck Sharp & Dohme Corp. 2010-11-30
NCT01105221 Acupuncture for Dry Eye https://ClinicalTrials.gov/show/NCT01105221 Completed Korea Institute of Oriental Medicine 2010-11-30
NCT01102257 Dry Eye Assessment and Management: Feasibility Study https://ClinicalTrials.gov/show/NCT01102257 Completed Asbell, Penny, M.D. 2010-07-31
NCT01101984 Study of DE-089 Ophthalmic Solution in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01101984 Completed Santen Pharmaceutical Co., Ltd. NA
NCT01077011 Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Lubricant Eye Gel https://ClinicalTrials.gov/show/NCT01077011 Completed Alcon Research 2010-01-31
NCT01076998 Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Eye Ointment https://ClinicalTrials.gov/show/NCT01076998 Completed Alcon Research 2010-01-31
NCT01061268 A Clinical Evaluation Pilot Study of the Efficacy of Blink® Tears Lubricant Eye Drops for the Relief of Dry Eye Symptoms Following Implantation of Tecnis® Multifocal Introcular Lens https://ClinicalTrials.gov/show/NCT01061268 Completed Innovative Medical 2012-02-29
NCT01057147 Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Subjects With Dry Eye - Effects on Central Cornea https://ClinicalTrials.gov/show/NCT01057147 Completed Kubota Vision Inc. 2011-01-31
NCT01051804 Evaluation of the Repeated Usage of Systane Ultra Eyedrop https://ClinicalTrials.gov/show/NCT01051804 Completed Alcon Research 2010-07-31
NCT01030237 An Evaluation of the Safety and Efficacy of FID 114657 https://ClinicalTrials.gov/show/NCT01030237 Completed Alcon Research 2010-01-31
NCT01027013 Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01027013 Completed Kubota Vision Inc. 2010-10-31
NCT01015209 Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers https://ClinicalTrials.gov/show/NCT01015209 Completed Medical University of Vienna 2010-10-31
NCT01014078 A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01014078 Completed Merck Sharp & Dohme Corp. 2010-03-31
NCT01013077 The Effect of a New Emulsion in Dry Eye Patients on Tear Layer Aberrometry, Contrast Sensitivity, and Reading Ability https://ClinicalTrials.gov/show/NCT01013077 Completed Southern California College of Optometry 2011-03-31
NCT01010282 Safety and Efficacy of Two Artificial Tears in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT01010282 Completed Allergan 2010-04-30
NCT00995189 Clinical Evaluation of the Causes of Contact Lens Related Dry Eye https://ClinicalTrials.gov/show/NCT00995189 Completed Alcon Research 2010-04-30
NCT00987727 Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye https://ClinicalTrials.gov/show/NCT00987727 Completed Allergan 2010-07-31
NCT00983203 Acute Comfort and Haze Profile of FID 114657 https://ClinicalTrials.gov/show/NCT00983203 Completed Alcon Research 2009-08-31
NCT00969280 Acupuncture for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00969280 Completed Korea Institute of Oriental Medicine 2009-12-31
NCT00946777 Barrier Function Measurement in Dry Eye Patients After Using Systane Ultra for 30 Days https://ClinicalTrials.gov/show/NCT00946777 Completed Alcon Research 2009-09-30
NCT00938951 Evaluate the Ability of Systane Ultra to Improve Subjective Symptoms of Ocular Irritation Post 60 Min. Athletic Performance. https://ClinicalTrials.gov/show/NCT00938951 Completed Alcon Research 2009-07-31
NCT00938704 Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms https://ClinicalTrials.gov/show/NCT00938704 Completed Allergan 2009-06-30
NCT00932477 Safety and Tolerability of Artificial Tears in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT00932477 Completed Allergan 2009-09-30
NCT00926185 A Study Evaluating the Efficacy of SAR 1118 (0.1%, 1.0%, 5.0%) Ophthalmic Solution in Subjects With Dry Eye Conducted in a Controlled Adverse Environment (CAE) https://ClinicalTrials.gov/show/NCT00926185 Completed Shire 2010-02-28
NCT00893139 A Study of AL-38583 Ophthalmic Solution 0.05%, 0.010% Versus AL-38583 Vehicle for Dry Eye https://ClinicalTrials.gov/show/NCT00893139 Completed Alcon Research 2010-01-31
NCT00885079 Confirmatory Study of OPC-12759 Ophthalmic Suspension https://ClinicalTrials.gov/show/NCT00885079 Completed Otsuka Pharmaceutical Co., Ltd. 2010-03-31
NCT00883649 Efficacy and Safety Study of Nutritional Supplements for Treatments of Dry Eye https://ClinicalTrials.gov/show/NCT00883649 Completed Virginia Eye Consultants 2011-12-31
NCT00851734 A Dose-Escalation Study to Assess the Safety and Tolerability of LX214 Ophthalmic Solution in Healthy Volunteers, Followed by an Open-Label Evaluation of LX214 in Patients With Keratoconjunctivitis Sicca (KCS) https://ClinicalTrials.gov/show/NCT00851734 Completed Lux Biosciences, Inc. 2009-03-31
NCT00840268 A Study of Hydroxypropyl Guar Galactomannan 0.25% (HPGG) Versus Vehicle in Dry Eye Patients https://ClinicalTrials.gov/show/NCT00840268 Completed Alcon Research 2009-07-31
NCT04093037 Analysis of the Diagnostic Performance of LacryDiag, a New Analyzer of the Ocular Surface in the Dry Eye https://ClinicalTrials.gov/show/NCT04093037 Recruiting Centre Hospitalier Universitaire de Saint Etienne 2021-07-31
NCT03878628 Treatment With Allogeneic Adipose-derived Mesenchymal Stem Cells in Patients With Aqueous Deficient Dry Eye Disease https://ClinicalTrials.gov/show/NCT03878628 Recruiting Rigshospitalet, Denmark 2020-04-30
NCT03461575 Efficacy and Safety of HU007 Eye Drops in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03461575 Completed Huons Co., Ltd. 2018-07-12
NCT03451396 Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms https://ClinicalTrials.gov/show/NCT03451396 Completed Lifelong Vision Foundation 2018-02-01
NCT00832130 Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye https://ClinicalTrials.gov/show/NCT00832130 Completed TearScience, Inc. 2009-06-30
NCT00831662 The Effects of Diquafosol Tetrasodium Ophthalmic Solution, 2% in Subjects With Dry Eye Disease (P08637) https://ClinicalTrials.gov/show/NCT00831662 Completed Merck Sharp & Dohme Corp. 2009-12-31
NCT03888183 Effect of Preservative-free Low-dose Hyaluronic Acid-containing Salt Solution on Dry Eye Disease https://ClinicalTrials.gov/show/NCT03888183 Recruiting Chang Gung Memorial Hospital 2020-01-22
NCT03768115 Autologous Plasma Treatment for Severe Dry Eye Patients https://ClinicalTrials.gov/show/NCT03768115 Recruiting Singapore National Eye Centre 2023-12-31
NCT03322917 Ocular Surface Syndrome Post-lasik, Outcomes of Treatment With Platelet Rich Plasma https://ClinicalTrials.gov/show/NCT03322917 Completed Vissum, Instituto Oftalmológico de Alicante 2013-01-17
NCT02986750 Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and Symptoms in Patients With Moderate to Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02986750 Completed Medical University of Vienna 2017-03-23
NCT02461719 Efficacy and Safety Study of TJCS for Treatment of Moderate to Severe Dry Eye Syndromes https://ClinicalTrials.gov/show/NCT02461719 Completed Taejoon Pharmaceutical Co., Ltd. 2014-09-30
NCT01890941 A Late Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes https://ClinicalTrials.gov/show/NCT01890941 Completed Kissei Pharmaceutical Co., Ltd. 2014-03-31
NCT00814944 A Dose-Ranging Clinical Study to Assess the Safety and Efficacy of Subconjunctival Injection of Sirolimus in Patients With Dry Eye in the Controlled Adverse Environmental (CAE) Model https://ClinicalTrials.gov/show/NCT00814944 Completed Santen Inc. 2009-10-31
NCT00814515 Double-Masked Trial of NOVA22007 (Ciclosporin 0.1%) Versus Vehicle in Patients With Moderate to Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00814515 Completed Santen SAS 2009-09-30
NCT00809198 Kynex Versus Refresh Plus Study in Subject With Dry Eye https://ClinicalTrials.gov/show/NCT00809198 Completed Alcon Research 2009-05-31
NCT01933165 Reproducibility of LipiView Ocular Surface Interferometer (LipiView) for Measuring Tear Lipid Layer Thickness https://ClinicalTrials.gov/show/NCT01933165 Completed Singapore National Eye Centre 2014-02-28
NCT01718028 The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT01718028 Completed Alcon Research 2012-10-31
NCT01387347 Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT01387347 Completed ReGenTree, LLC 2011-10-31
NCT00804791 Residence Time Evaluation of Marketed OTC Ophthalmic Products https://ClinicalTrials.gov/show/NCT00804791 Completed Alcon Research 2009-02-28
NCT00802399 Partial Lacrimal Punctual Occlusion https://ClinicalTrials.gov/show/NCT00802399 Completed University of Sao Paulo General Hospital 2008-11-30
NCT04063735 Alleviating Effects Against Dry Eye by Oral Intake of Cordyceps Cicadae Mycelia https://ClinicalTrials.gov/show/NCT04063735 Completed Chung Shan Medical University 2017-02-07
NCT03089580 Intense Pulsed Light Study for Dry Eye Disease https://ClinicalTrials.gov/show/NCT03089580 Completed University of Michigan 2018-11-01
NCT03048526 Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease https://ClinicalTrials.gov/show/NCT03048526 Completed Novaliq GmbH 2017-04-18
NCT02985827 Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra) https://ClinicalTrials.gov/show/NCT02985827 Completed ORA, Inc. 2016-01-31
NCT02492412 Efficacy and Safety of HE10 for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02492412 Completed Huons Co., Ltd. 2014-07-31
NCT02554084 Optical Coherence Tomography of Tear Film Dynamics In-Vivo https://ClinicalTrials.gov/show/NCT02554084 Completed University of Rochester 2017-09-30
NCT02066896 Laser Therapy to Treat the Dry Mouth of Sjogren’s Syndrome https://ClinicalTrials.gov/show/NCT02066896 Completed Federal University of São Paulo 2016-08-31
NCT03920215 Clinical Trial to Evaluate the Long Term Follow up of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET Study) https://ClinicalTrials.gov/show/NCT03920215 Completed Oyster Point Pharma, Inc. 2019-10-12
NCT03848221 Direct Application of Systane Complete to Contact Lenses https://ClinicalTrials.gov/show/NCT03848221 Completed University of Alabama at Birmingham 2019-10-20
NCT01086774 Efficacy of Systane Balance to Stabilize the Tear Film in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT01086774 Completed Alcon Research 2010-11-30
NCT00788229 Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00788229 Completed Dhp Korea Co., Ltd. 2009-08-31
NCT00784719 A Prospective, Randomized, Placebo and Active Comparator Controlled Study of CP-690,550 in Subjects With Dry Eye. https://ClinicalTrials.gov/show/NCT00784719 Completed Pfizer 2009-10-31
NCT00781092 A Prospective, Randomized, Double-Masked, Single Center, Clinical Comparison of the Use of Systane Ultra in the Management of Dry Eyes in Bilateral Eyes https://ClinicalTrials.gov/show/NCT00781092 Completed Durrie Vision 2009-03-31
NCT00779987 Autologous Serum Efficacy Study in Patients With Severe Dry Eye https://ClinicalTrials.gov/show/NCT00779987 Completed University of Chile 2008-12-31
NCT00765804 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Dry Eye https://ClinicalTrials.gov/show/NCT00765804 Completed Eyegate Pharmaceuticals, Inc. 2009-02-28
NCT00761202 Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms https://ClinicalTrials.gov/show/NCT00761202 Completed Allergan 2008-06-30
NCT00760045 Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time https://ClinicalTrials.gov/show/NCT00760045 Completed Alcon Research 2008-10-31
NCT00758784 Safety and Efficacy of an Ophthalmic Solution in Dry Eye Disease https://ClinicalTrials.gov/show/NCT00758784 Completed Bausch & Lomb Incorporated 2009-06-30
NCT00756093 Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops https://ClinicalTrials.gov/show/NCT00756093 Completed Alcon Research 2008-09-30
NCT00748865 Acute Comfort and Blur of Systane Ultra and Systane https://ClinicalTrials.gov/show/NCT00748865 Completed Alcon Research 2008-08-31
NCT00743249 Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers https://ClinicalTrials.gov/show/NCT00743249 Completed Alcon Research 2009-02-28
NCT00739713 Effects of Sea Buckthorn Oil on Dry Eye https://ClinicalTrials.gov/show/NCT00739713 Completed University of Turku 2009-03-31
NCT00739349 NOVA22007 0.05% and 0.1% Cyclosporine Versus Vehicle for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00739349 Completed Santen SAS 2009-01-31
NCT00735865 Lid Margin And Conjunctival Microbial Flora Following Punctum Occlusion https://ClinicalTrials.gov/show/NCT00735865 Completed Lahey Clinic 2009-04-30
NCT00724412 Evaluate Artificial Tear Efficacy in Moderate to Severe Dry Eye https://ClinicalTrials.gov/show/NCT00724412 Completed Alcon Research 2009-02-28
NCT00721656 Phase 2 Study of KLS-0611 in Patients With Dry Eye Syndromes https://ClinicalTrials.gov/show/NCT00721656 Completed Kissei Pharmaceutical Co., Ltd. NA
NCT00681265 Tear Film Break-up Time After Instillation of Artificial Tears https://ClinicalTrials.gov/show/NCT00681265 Completed Eyeon Therapeutics, Inc. 2008-08-31
NCT00680108 A Study to Determine the Safety and Tolerability of Escalating Doses of INS365 Ophthalmic Solution https://ClinicalTrials.gov/show/NCT00680108 Completed Merck Sharp & Dohme Corp. 2000-05-31
NCT00679718 A Study of INS365 Ophthalmic Solution in Patients With Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT00679718 Completed Merck Sharp & Dohme Corp. 2000-07-31
NCT00673959 Acute Comfort of Lubricant Eye Drop FID 111421 https://ClinicalTrials.gov/show/NCT00673959 Completed Alcon Research 2008-02-29
NCT00673855 Acute Comfort of Lubricant Eye Drops FID 112903 https://ClinicalTrials.gov/show/NCT00673855 Completed Alcon Research 2008-05-31
NCT00667004 Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease https://ClinicalTrials.gov/show/NCT00667004 Completed Bausch & Lomb Incorporated 2008-12-31
NCT00622037 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality https://ClinicalTrials.gov/show/NCT00622037 Completed Bp Consulting, Inc 2008-05-31
NCT00620893 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK). https://ClinicalTrials.gov/show/NCT00620893 Completed Bp Consulting, Inc 2009-05-31
NCT00610480 Effects of Tear Film Stability After Instillation Of OTC Artificial Drops https://ClinicalTrials.gov/show/NCT00610480 Completed University of Texas Southwestern Medical Center 2009-03-31
NCT00607776 Artificial Tears Study in Mild to Moderate Dry Eye Patients https://ClinicalTrials.gov/show/NCT00607776 Completed Abbott Medical Optics NA
NCT00600288 Study of the Effect of Diquafosol Tetrasodium Ophthalmic Solution, 2% Versus Placebo in Dry Eye Subjects (P08634) https://ClinicalTrials.gov/show/NCT00600288 Completed Merck Sharp & Dohme Corp. 2008-05-31
NCT00599716 Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00599716 Completed Lantibio 2008-04-30
NCT00568386 Acute Comfort and Blur of Systane and Optive https://ClinicalTrials.gov/show/NCT00568386 Completed Alcon Research NA
NCT00567177 Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease https://ClinicalTrials.gov/show/NCT00567177 Completed Innovative Medical NA
NCT00565669 Evaluation of Blink Tears and Systane Concomitant With Restasis for the Treatment of Dry Eye Symptoms https://ClinicalTrials.gov/show/NCT00565669 Completed Medical University of South Carolina 2008-10-31
NCT00560638 Loteprednol Etabonate Opthalmic Suspension for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00560638 Completed Bausch & Lomb Incorporated 2006-02-28
NCT00554879 Acupuncture Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00554879 Completed Walter Reed Army Medical Center 2011-02-28
NCT00549289 Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-006) https://ClinicalTrials.gov/show/NCT00549289 Completed Sirion Therapeutics, Inc. NA
NCT00548301 Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-007) https://ClinicalTrials.gov/show/NCT00548301 Completed Sirion Therapeutics, Inc. NA
NCT00535054 Study to Assess the Safety and Patients’ Satisfaction of Tears Again* in the Treatment of Dry Eye Symptoms https://ClinicalTrials.gov/show/NCT00535054 Completed Trima, Israel Pharmaceutical Products 2010-02-28
NCT00520260 Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase https://ClinicalTrials.gov/show/NCT00520260 Completed Florida Eye Microsurgical Institute 2008-08-31
NCT00514852 Safety and Efficacy of an Artificial Tear for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00514852 Completed Allergan 2008-01-31
NCT00502073 Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005) https://ClinicalTrials.gov/show/NCT00502073 Completed Sirion Therapeutics, Inc. NA
NCT00475319 Late Phase 2 Study of OPC-12759 Ophthalmic Suspension https://ClinicalTrials.gov/show/NCT00475319 Completed Otsuka Pharmaceutical Co., Ltd. 2008-03-31
NCT00471419 Phase II Study of AL-2178 (FID 109980) in the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00471419 Completed Alcon Research 2007-08-31
NCT00469573 Safety and Efficacy of Optive in Contact Lens Wearers With Dry Eyes https://ClinicalTrials.gov/show/NCT00469573 Completed Innovative Medical 2008-03-31
NCT00442273 Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00442273 Completed Chonnam National University Hospital NA
NCT00439400 A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period https://ClinicalTrials.gov/show/NCT00439400 Completed Alacrity Biosciences, Inc. NA
NCT00426543 Effect of B-cell Depletion in Patients With Primary Sjögren’s Syndrome https://ClinicalTrials.gov/show/NCT00426543 Completed University of Copenhagen 2010-06-30
NCT00799682 Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z® https://ClinicalTrials.gov/show/NCT00799682 Completed Ophthalmic Consultants of Long Island 2011-01-31
NCT00799552 Safety and Efficacy Study of RX-10045 on the Signs and Symptoms of Dry Eye https://ClinicalTrials.gov/show/NCT00799552 Completed Resolvyx Pharmaceuticals, Inc 2009-05-31
NCT00407043 Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis https://ClinicalTrials.gov/show/NCT00407043 Completed Ophthalmic Consultants of Long Island 2007-09-30
NCT00405457 Efficacy and Safety of a New Multi-dose Lubricant Eye Drop Concomitant With Restasis® (Cyclosporine A) for the Treatment of Dry Eye Symptoms https://ClinicalTrials.gov/show/NCT00405457 Completed Innovative Medical 2008-01-31
NCT00404131 Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00404131 Completed Merck Sharp & Dohme Corp. 2001-12-31
NCT00403975 Study of Diquafosol Tetrasodium Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00403975 Completed Merck Sharp & Dohme Corp. 2004-11-30
NCT00403715 Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00403715 Completed Merck Sharp & Dohme Corp. 2002-09-30
NCT00399230 A Comparison of Optive in Patients Previously Using Systane for the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00399230 Completed Innovative Medical NA
NCT00399061 Efficacy of Optive Versus Systane Concomitant With Restasis (Cyclosporine A) for the Treatment of Dry Eye Symptoms https://ClinicalTrials.gov/show/NCT00399061 Completed Innovative Medical 2008-09-30
NCT00395759 The Visual Effect of an Investigational Artificial Tear in the Tear Layer. https://ClinicalTrials.gov/show/NCT00395759 Completed Southern California College of Optometry NA
NCT00388791 Comparison of Systane Free vs. Saline in the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00388791 Completed Southern California College of Optometry NA
NCT00386646 Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITEâ„¢) Versus 0.5% Carboxymethylcellulose in the Treatment of Dry Eye https://ClinicalTrials.gov/show/NCT00386646 Completed Chulalongkorn University NA
NCT00370747 Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00370747 Completed Bausch & Lomb Incorporated 2007-06-30
NCT00357201 Efficacy of T1675 Versus Placebo in Patients With Bilateral Treated Moderate Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00357201 Completed Laboratoires Thea NA
NCT00349466 Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca https://ClinicalTrials.gov/show/NCT00349466 Completed Can-Fite BioPharma 2009-05-31
NCT00349440 Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy https://ClinicalTrials.gov/show/NCT00349440 Completed Innovative Medical 2008-09-30
NCT00345241 Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points https://ClinicalTrials.gov/show/NCT00345241 Completed University of Texas Southwestern Medical Center 2006-12-31
NCT00344721 A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00344721 Completed University of Texas Southwestern Medical Center 2008-10-31
NCT00335114 Efficacy of Cyclosporine Ophthalmic Emulsion in the Treatment of Dry Eye Syndrome in Contact Lens Wearers https://ClinicalTrials.gov/show/NCT00335114 Completed University of Alabama at Birmingham NA
NCT00234078 Dose-response Study of OPC-12759 Ophthalmic Suspension https://ClinicalTrials.gov/show/NCT00234078 Completed Otsuka Pharmaceutical Co., Ltd. 2006-04-30
NCT00201981 Study of Rebamipide Eye Drops to Treat Dry Eye https://ClinicalTrials.gov/show/NCT00201981 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. NA
NCT00201955 Study of Rebamipide Eye Drops to Treat Dry Eye https://ClinicalTrials.gov/show/NCT00201955 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. NA
NCT00198536 Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00198536 Completed Bausch & Lomb Incorporated 2005-12-31
NCT00128245 Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis Sicca https://ClinicalTrials.gov/show/NCT00128245 Completed Novartis 2006-12-31
NCT00001731 Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops https://ClinicalTrials.gov/show/NCT00001731 Completed National Institutes of Health Clinical Center (CC) NA
NCT00037661 Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye https://ClinicalTrials.gov/show/NCT00037661 Completed Merck Sharp & Dohme Corp. 2003-03-31
NCT00818324 Long Term Administration Study of OPC-12759 Ophthalmic Suspension https://ClinicalTrials.gov/show/NCT00818324 Completed Otsuka Pharmaceutical Co., Ltd. 2010-09-30
NCT00025818 Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00025818 Completed Allergan 2003-03-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04458012 Epidemiological Study of Dry Eye Disease in Stavanger: Dry Eye Disease in Patients Treated With Intravitreal Injections https://ClinicalTrials.gov/show/NCT04458012 Enrolling by invitation Helse Stavanger HF 2023-06-25
NCT03364322 Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease https://ClinicalTrials.gov/show/NCT03364322 Completed Hallym University Kangnam Sacred Heart Hospital 2017-06-30
NCT03358979 Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE) https://ClinicalTrials.gov/show/NCT03358979 Recruiting Fondation Ophtalmologique Adolphe de Rothschild 2021-12-31
NCT03061578 Evaluation of Dry Eye by Tear Film Imager in a Low Humidity Environmental Exposure Chamber (TFI-LH16) https://ClinicalTrials.gov/show/NCT03061578 Completed Adom Advanced Optical Technologies Ltd. 2017-03-11
NCT02851654 Interest of Eye Movement Measurements in the Comprehension of Dry Eyes Symptoms https://ClinicalTrials.gov/show/NCT02851654 Completed Fondation Ophtalmologique Adolphe de Rothschild 2019-10-30
NCT02715323 Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT02715323 Recruiting Singapore National Eye Centre 2020-07-31
NCT02712762 Ocular Surface Disease in Chronic Graft-Versus-Host Disease (GVHD) Patients https://ClinicalTrials.gov/show/NCT02712762 Recruiting Singapore National Eye Centre 2020-11-30
NCT02585414 Assessment of TFT by OCT in Healthy Subjects and Subjects With DES https://ClinicalTrials.gov/show/NCT02585414 Recruiting Medical University of Vienna 2020-01-31
NCT03399292 Effect of Lipid Based Eye Drops on Tear Film Lipid Layer Thickness https://ClinicalTrials.gov/show/NCT03399292 Recruiting Medical University of Vienna 2020-12-31
NCT02522312 A Retrospective Analysis of Restasis® Benefits in Dry Eye Contact Lens Patients https://ClinicalTrials.gov/show/NCT02522312 Completed Hazleton Eye Specialists 2015-12-31
NCT02376556 The Effect of Eyelid Surgery on Dry Eye - a Prospective Study https://ClinicalTrials.gov/show/NCT02376556 Completed Sheba Medical Center 2018-03-31
NCT02252744 Prevalence of Dry Eye Disease in Patients Diagnosed With Rheumatoid Arthritis https://ClinicalTrials.gov/show/NCT02252744 Completed Western University of Health Sciences 2014-06-30
NCT02161341 Ocular Surface Microbiome in Dry Eye Patients https://ClinicalTrials.gov/show/NCT02161341 Completed Singapore National Eye Centre 2018-10-31
NCT02111928 NovaTears® Eye Drops Observational Study https://ClinicalTrials.gov/show/NCT02111928 Completed Novaliq GmbH 2014-05-31
NCT02042820 Ocular Surface Immune Response in Dry Eye Disease https://ClinicalTrials.gov/show/NCT02042820 Completed Tufts Medical Center 2015-07-31
NCT01988597 Dry Eye Symptoms and Quality of Life https://ClinicalTrials.gov/show/NCT01988597 Completed Singapore National Eye Centre 2014-04-30
NCT01942226 Investigation on Medical Management of Dry Eye Patients https://ClinicalTrials.gov/show/NCT01942226 Completed National Cheng Kung University 2013-11-30
NCT01882413 A Study to Determine the Prevalence of Inflammatory Dry Eye Disease in Patients Prior to Cataract Removal https://ClinicalTrials.gov/show/NCT01882413 Completed Allergan 2014-03-31
NCT01854905 An Observational Study of Dry Eye Prior to Laser-Assisted in Situ Keratomileusis (LASIK) Therapy https://ClinicalTrials.gov/show/NCT01854905 Completed Allergan 2013-09-30
NCT01826812 Impairment of Reading Ability in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01826812 Completed Johns Hopkins University 2015-11-30
NCT01711424 An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT01711424 Completed Allergan 2013-03-31
NCT01684852 Non Interventional Study to Evaluate the Efficacy and Tolerability of Ectoin Containing Ophthalmic Solution https://ClinicalTrials.gov/show/NCT01684852 Completed Bitop AG 2012-12-31
NCT01679015 Evaluating Patients With Eye Allergies and Determining if There Are Also Dry Eyes https://ClinicalTrials.gov/show/NCT01679015 Completed Schwartz Laser Eye Center 2014-02-28
NCT01611922 Optimization of Assessment and Grading for Lid Wiper Epitheliopathy https://ClinicalTrials.gov/show/NCT01611922 Completed Alcon Research 2012-05-31
NCT01547936 Effect of Controlled Adverse Environment (CAE) on Tear Film Stability https://ClinicalTrials.gov/show/NCT01547936 Completed ORA, Inc. 2012-02-29
NCT01507025 The Effect of Hinge Location on Corneal Sensation and Dry Eye After LASIK: A Systematic Review and Meta-analysis https://ClinicalTrials.gov/show/NCT01507025 Completed Wenzhou Medical University 2014-02-28
NCT01496482 Comparison of Evaporimetry With the Established Methods of Tear Film Measurement https://ClinicalTrials.gov/show/NCT01496482 Completed University of Zagreb 2009-02-28
NCT01321424 Diurnal Variation in Tear Osmolarity https://ClinicalTrials.gov/show/NCT01321424 Completed Ophthalmic Consultants of Long Island 2016-02-29
NCT04043949 The Influences of Dry Eye Disease on Optical Quality https://ClinicalTrials.gov/show/NCT04043949 Completed Peking University Third Hospital 2018-07-01
NCT03938207 Taiwan Biobank Among Dry Eye Syndrome, Healthy Control in Taiwan https://ClinicalTrials.gov/show/NCT03938207 Active, not recruiting Taipei Veterans General Hospital, Taiwan 2019-05-01
NCT03866629 The Effect Of Lifitegrast On Refractive Accuracy And Symptoms In Dry Eye Patients Undergoing Cataract Surgery https://ClinicalTrials.gov/show/NCT03866629 Completed MDbackline, LLC 2019-10-29
NCT03753893 Ocular Manifestations in Rheumatic Diseases https://ClinicalTrials.gov/show/NCT03753893 Active, not recruiting Lawson Health Research Institute 2020-10-01
NCT01254201 The Pathogenesis of Idiopathic Dry Eyes https://ClinicalTrials.gov/show/NCT01254201 Completed University of Michigan 2015-12-31
NCT01206244 Diurnal Variation of Tear Meniscus and Tear Osmolarity https://ClinicalTrials.gov/show/NCT01206244 Completed University of Miami 2011-09-30
NCT01176045 TearLab Refractive Surgery Dry Eye Study https://ClinicalTrials.gov/show/NCT01176045 Completed TearLab Corporation 2011-12-31
NCT01161771 Effects of Cataract Extraction Surgery and Limbal Relaxing Incision on Corneal Sensation and Dry Eye https://ClinicalTrials.gov/show/NCT01161771 Completed Allergan 2010-12-31
NCT01016405 Prospective Health Assessment of Cataract Patients’ Ocular Surface https://ClinicalTrials.gov/show/NCT01016405 Completed Innovative Medical 2010-09-30
NCT01014780 Tear Film Thickness Measured Using a Novel Technique https://ClinicalTrials.gov/show/NCT01014780 Completed Southern California College of Optometry 2010-04-30
NCT00991679 CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00991679 Completed Chonnam National University Hospital 2008-10-31
NCT00893243 Efficacy Comparative Study Between Tears Again®, Opticol® and Optive® https://ClinicalTrials.gov/show/NCT00893243 Completed Hospital de Sao Sebastiao NA
NCT00854906 Keratometric Tear Breakup Time and Fluorescein Tear Breakup Time https://ClinicalTrials.gov/show/NCT00854906 Completed University of Arkansas 2009-06-30
NCT00848198 TearLab Core Validation Study to Establish Referent Values for Dry Eye Disease https://ClinicalTrials.gov/show/NCT00848198 Completed TearLab Corporation 2011-03-31
NCT00833235 A Natural History Study of Patients With Dry Eye https://ClinicalTrials.gov/show/NCT00833235 Completed Allergan 2017-03-06
NCT00827255 Physician’s Evaluation of Cyclosporine Ophthalmic Emulsion 0.05% https://ClinicalTrials.gov/show/NCT00827255 Completed Allergan 2009-06-30
NCT00809003 Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00809003 Completed University of Waterloo NA
NCT03937271 Objective Measurement Methods for Autoimmune Disease and Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT03937271 Active, not recruiting Taipei Veterans General Hospital, Taiwan 2019-05-31
NCT00769665 A 2-week Clinical Comparison of SYSTANE® Ultra to Sensitive Eyes Rewetting Drops in Contact Lens Wearing Patients. https://ClinicalTrials.gov/show/NCT00769665 Completed Alcon Research 2009-01-31
NCT00717418 Efficacy Study of Cyclosporine Ophthalmic Emulsion in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00717418 Completed Allergan 2006-08-31
NCT00706940 Tear Dynamics After Restasis Treatment in Dry Eye Patients https://ClinicalTrials.gov/show/NCT00706940 Completed University of Miami 2016-12-31
NCT00553579 The Relationship of Residence Time and Visual Effect of Optive and Systane in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT00553579 Completed Southern California College of Optometry 2008-05-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02011776 A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Syndrome https://ClinicalTrials.gov/show/NCT02011776 Completed Santen Pharmaceutical(China) Co.,LTD 2013-08-31
NCT04413370 Dry Eye Screening and Referral System https://ClinicalTrials.gov/show/NCT04413370 Recruiting Sun Yat-sen University 2020-08-06
NCT04109170 Dry Eye Evaluation System Based on Bioinformatics https://ClinicalTrials.gov/show/NCT04109170 Recruiting Huaxia Eye Hospital Group 2019-12-23
NCT03652415 DRy Eye Outcome and Prescription Study https://ClinicalTrials.gov/show/NCT03652415 Recruiting Guy’s and St Thomas’ NHS Foundation Trust 2021-08-23